- Product Name 3-METHOXYMORPHINAN HCL
- cas 1531-25-5
- purity 99%
Pharmaceutical
Cost-effective and customizable 3-METHOXYMORPHINAN HCL 1531-25-5 in stock
- Molecular Formula: C17H23 N O
- Molecular Weight: 257.376
- Vapor Pressure: 0mmHg at 25°C
- Boiling Point: 403.2°Cat760mmHg
- Flash Point: 167.1°C
- PSA： 21.26000
- Density: 1.12g/cm3
- LogP: 3.37000
3-METHOXYMORPHINAN HCL(Cas 1531-25-5) Usage
|
General Description |
3-Methoxymorphinan HCl, or 3-Methoxy-N-methyl-morphinan hydrochloride, is a chemical derived from the morphinan group of opioids, which includes drugs like morphine. It is typically used for research purposes, especially in the study of the human body's reaction to opioids and potential treatments for opioid addiction. Its chemical formula is C18H24NO2·HCl, it contains 22.07% nitrogen, 6.96% hydrogen, and 30.64% chlorine in its molecular composition. Not intended for human consumption, it must be handled with care due to its potential toxicity and it falls under the category of controlled substances in many jurisdictions. |
InChI:InChI=1/C17H23NO/c1-19-13-6-5-12-10-16-14-4-2-3-7-17(14,8-9-18-16)15(12)11-13/h5-6,11,14,16,18H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
1531-25-5 Relevant articles
N-demethylation of dextromethorphan
Peet
, p. 1447 - 1448 (1980)
-
ANALOGS OF DEXTROMETHORPHAN WITH BALANCED RECEPTOR ACTIVITIES
-
Paragraph 0073-0075, (2022/03/09)
Substituted analogs of dextromethorphan ...
Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues
Altman, Ryan A.,Ambler, Brett R.,Sorrentino, Jacob P.
, p. 5416 - 5427 (2020/05/19)
We report the conversion of aryl methyl ...
CYP2D6 allelic variants *34, *17-2, *17-3, and *53 and a Thr309Ala mutant display altered kinetics and NADPH coupling in metabolism of bufuralol and dextromethorphan and altered susceptibility to inactivation by SCH 66712
Glass, Sarah M.,Martell, Cydney M.,Oswalt, Alexandria K.,Osorio-Vasquez, Victoria,Cho, Christi,Hicks, Michael J.,Mills, Jacqueline M.,Fujiwara, Rina,Glista, Michael J.,Kamath, Sharat S.
supporting information, p. 1106 - 1117 (2018/08/12)
Metabolic phenotype can be affected by m...
COMPOSITIONS AND METHODS THEREOF
-
Paragraph 00535, (2018/03/25)
Compounds of formula I, (I) or enantiome...
1531-25-5 Process route
-
-
125-70-2,1453167-99-1
levomethorphan
-
-
1531-25-5
(-)-3-Methoxymorphinan
Conditions
| Conditions | Yield |
|---|---|
|
levomethorphan;
With
carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate;
In
1,2-dichloro-ethane;
for 48h;
Heating;
With
methanol;
for 3h;
Further stages.;
Heating;
|
90%
|
|
levomethorphan;
With
bromocyane;
In
dichloromethane;
Inert atmosphere;
Reflux;
With
potassium hydroxide;
In
diethylene glycol;
at 160 ℃;
for 2h;
|
85%
|
|
levomethorphan;
With
carbonochloridic acid 1-chloro-ethyl ester;
With
methanol;
|
|
|
With
carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate;
In
1,2-dichloro-ethane;
for 6h;
Heating;
|
|
|
Multi-step reaction
with
2
steps
1: benzene / 1 h / Heating
2: 1.) aq. acetic acid, zinc powder, 2.) aq. NaOH / 1.) 20 min, 2.) chloroform
With
sodium hydroxide; acetic acid; zinc;
In
benzene;
|
-
-
77-07-6,125-73-5,297-90-5,2616-02-6,59684-82-1
Levorphanol
-
-
1531-25-5
(-)-3-Methoxymorphinan
Conditions
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1.1: 99 percent / diethyl ether; methanol / 20 °C
2.1: NaHCO3
; 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 48 h / Heating
2.2: 90 percent / MeOH / 3 h / Heating
With
carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate;
In
methanol; diethyl ether; 1,2-dichloro-ethane;
|
|
|
Multi-step reaction
with
2
steps
2.1: 1-chloroethyl chloroformate
2.2: MeOH
With
carbonochloridic acid 1-chloro-ethyl ester;
1.1: Methylation / 2.1: Substitution / 2.2: solvolysis;
|
1531-25-5 Upstream products
-
125-71-3
dextromethorphan
-
67-56-1
methanol
-
83607-50-5
3-methoxy-N-chloromorphinan
-
125-70-2
levomethorphan
1531-25-5 Downstream products
-
1531-12-0
norlevorphanol
-
4163-15-9
cyclorphan
-
152-02-3
levallorphan
-
1079043-47-2
(4bS,8aS,9S)-ethyl 3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate
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